ST. LOUIS – Three people were hospitalized early Thursday morning after an overnight crash along River Des Peres in south St. Louis.

The crash took place shortly before 3 a.m. on River Des Peres Boulevard near Parkway Lane, involving a Chevy Avalanche and a Ford EcoSport.

Early indications suggest that the crash happened after the Chevy Avalanche may have crossed the center line, colliding head-on with the Ford EcoSport.

Three people were left injured after the crash, with one sustaining critical injuries. The conditions of the other individuals involved in the crash are unknown.

Authorities shut down nearly a mile-long stretch of River Des Peres Boulevard as they investigated the crash. First responders worked for approximately 30 minutes to extricate one of the individuals out of a vehicle.

An investigation into the crash is ongoing. Accident reconstruction investigators have been called to the scene to determine the cause of the crash.

All facts from this article were gathered by KTVI journalists. This article was converted into this format with assistance from artificial intelligence. It has been edited and approved by KTVI staff.